Inflammatory nodules in the testicles are benign lesions that do not pose a risk to human life. However, for unmarried men there is a certain impact, it may cause the destruction of the varicocele, or it may lead to the obstruction of the vas deferens, causing the sperm produced by one testicle not to be smoothly discharged from the body, that is, for increasing the risk of infertility of the patient. In the early stage of inflammation, early treatment is needed so that the probability of inflammatory nodule formation can be reduced. The later the treatment, the higher the probability of inflammatory nodule formation. For men who are married and do not have fertility requirements, there is no impact. Inflammatory nodules are usually not associated with any painful symptoms, but they can persist for a long time. Recurrence of inflammation can occur when the body’s immunity decreases. In patients with recurrent inflammatory nodules, surgical excision of localized inflammatory nodules may be considered to prevent recurrence.