High uric acid is known as hyperuricemia, and a biochemical definition of hyperuricemia is a urate concentration of more than 416 mmol/L. It is caused by an overproduction of urate, an absolute or relative decrease in renal clearance of uric acid, or a combination of both of these causes. Of course, there are also genetic factors, coexisting disease-related factors, and environmental factors, i.e., medications, diet, or exposure to toxins. There are three major disease associations with hyperuricemia, gout, urate nephropathy, and kidney stones, with acute urate nephropathy being life-threatening. For urates >480 mmol/L, medication is required. It is also important to note that it is more important to reduce to an ideal weight by reducing moderation and restructuring the diet, avoiding alcohol and sugary drinks, and regular physical activity.