Migraine is a common clinical primary headache with chronic attack characteristics. A variety of factors may trigger migraine attacks, such as mental tension, emotional excitement, overexertion, and cold. When the body is asleep at night, the body’s defense mechanism is lowered, such as the room temperature is too low, not paying attention to warmth, etc., resulting in body stimulation, and may also suddenly wake up in the middle of the night with migraine. If the patient has primary headache disease, such as cluster headache, the attack is mostly in the evening and the headache is more intense, which can usually be relieved by itself. In addition, if a patient has cerebrovascular disease such as cerebral hemorrhage, he may also wake up in the middle of the night with a migraine due to spontaneous rupture of blood vessels in the cerebellum or the thalamus of the basal ganglia, which then stimulates the surrounding brain nerves. Therefore, if a patient wakes up in the middle of the night with a sudden migraine, he or she can take medication to relieve the symptoms if there is a clear medical history and he or she has taken medication under the guidance of a doctor. For patients with unexplained symptoms, it is recommended to seek medical advice to determine the cause and not to take medication at home or to avoid emotional or strenuous activities to avoid other symptoms.