Which treatment is best for endometrial hyperplasia simplex needs to be considered on a comprehensive basis. Endometrial simple hyperplasia can be treated by regular administration of progestational drugs such as dextroprogesterone, intrauterine placement of levonorgestrel intrauterine slow-release system, and surgical removal of the uterine lining, etc. The specific treatment plan needs to be decided by the doctor in conjunction with the clinic, taking into account the patient’s condition and adherence. Endometrial simple hyperplasia refers to endometrial glandular hyperplasia with irregular size and morphology, and the ratio of glands to mesenchyme is higher than that of endometrium in proliferative stage, but there are no obvious atypical cells. The main manifestation is irregular uterine bleeding. It may progress to endometrial complex hyperplasia and endometrial cancer, and its treatment is categorized into drug treatment and surgical treatment. 1. Pharmacological treatment: those who have fertility requirements or refuse surgery can choose oral progestational drugs or intrauterine levonorgestrel intrauterine release system to inhibit endometrial hyperplasia. Oral medications need to be taken daily for a long period of time, and if the medication is missed, abnormal bleeding may occur. Intrauterine placement of levonorgestrel intrauterine slow-release system is simpler, but there are risks of ring displacement, detachment, abnormal bleeding, abdominal pain, etc. 2. Surgery: If the conservative drug treatment is ineffective or the patient does not want to take the drug treatment, or if the patient is old, does not want to have children, or has the risk of cancer, surgical treatment can be considered, including endometrial removal, hysterectomy, and so on. Patients with simple endometrial hyperplasia need to go to the hospital in time for treatment, determine the treatment plan under the guidance of the doctor, and review the endometrial condition on a regular basis, do not blindly use medication on your own to avoid delaying the condition.