If you have pain in the middle of your chest and hiccups all the time, you should first consider gastroesophageal reflux disease, esophageal stenosis, mediastinitis, gastritis, and gastric insufficiency. It is recommended that patients actively seek medical advice to clarify the causes and give reasonable treatment and handling. Common causes and treatment 1, gastroesophageal reflux disease: Due to abnormal reflux of stomach and duodenal contents into the esophagus, it can cause symptoms such as pain in the middle of the chest and hiccups, and can lead to esophagitis and damage to tissues other than the esophagus such as the pharynx, larynx and trachea. Patients need to take medication, surgery, endoscopic treatment and other methods according to the severity of the disease. Medication is commonly used to relieve symptoms with H2 receptor antagonists, proton pump inhibitors, gastric mucosal protectors, and prokinetic drugs; 2. Esophageal stricture: If GERD continues to worsen, it can lead to esophageal stricture, and patients will have symptoms of pain in the middle of the chest and hiccups, in addition to swallowing difficulties. Medication needs to be given early, and if the stenosis is more serious, endoscopic dilatation therapy can be taken; 3. Mediastinitis: Patients can experience pain behind the sternum, and if the inflammation stimulates the phrenic nerve or diaphragm, it can cause eructation. It is recommended to drain as soon as possible, use appropriate antibiotics to control the infection, and perform surgery if necessary; 4. Gastritis and gastric insufficiency: due to inflammation in the stomach or low function, gastric distention can easily occur, which can stimulate the diaphragm and cause hiccup symptoms. It is recommended to improve the diet and give H2 receptor antagonists, proton pump inhibitors, and prokinetic drugs. Caution: Pay extra attention to dietary modification when such symptoms occur, do not overeat or overeat, avoid smoking, alcohol, coffee, chocolate, acid food and food with high fat content, do not lie down immediately after meals, and obese people need to lose moderate weight.