Grade III thyroid nodules are graded under thyroid ultrasound. Grade III thyroid nodules are usually benign nodules, but malignancy cannot be ruled out, and the indication for thyroid surgery is mainly based on symptoms and type. If the nodules are benign and present with symptoms of pressure or affect the appearance, they should be surgically removed, and if they are malignant, they should also be surgically treated. 1. Benign thyroid nodules need to be surgically removed if they produce compression symptoms, such as difficulty breathing or swallowing. 2. Benign thyroid nodules that do not cause pressure symptoms, but have an enlarged thyroid gland that affects the patient’s work and life, as well as seriously affecting his or her appearance, can be surgically removed. 3. If a fine-needle aspiration biopsy is performed, and if the biopsy result is malignant, timely surgery is also needed. To summarize, it is recommended that patients with grade 3 thyroid gland undergo further examination, and at the same time, closely observe their own symptoms and consult a doctor in time if any abnormality occurs.