Cranial defects are mostly caused by trauma and cause very serious pain to those who suffer from them. Cranial defects can affect the physical and mental health of patients, so it is important to perform cranial repair surgery as early as possible. Cranial defects are one of the common and diverse human congenital anomalies that seriously affect the physical and mental health and quality of life of patients, especially large cranial defects caused by trauma, tumor removal and vascular injury. Currently, the common treatments used for cranial bone injuries are autologous bone and allogeneic bone grafts. However, autologous bone grafts often face the challenges of shape matching and limited sources, and allogeneic bone grafts are prone to immune rejection. Because of skull repair, many skull repair materials have “emerged,” with titanium mesh and PEEK being widely used. Although titanium mesh has its advantages, there are still many disadvantages. Titanium mesh manufacturers are disorganized, and because of the high technical requirements of titanium processing, the quality of shaping varies, especially for patients with osteoporosis, and poor fitting problems often occur. Second, titanium mesh is affected by temperature. Moreover, due to the inherent deficiencies of titanium mesh, it is difficult to perfectly shape the curved parts of the head, such as the forehead and the arch of the eyebrows, and there may be traces of mesh after implantation, making the visual effect less favorable. PEEK (polyetheretherketone) is a special engineering plastic that looks similar to ordinary plastic, but has many advantages such as high temperature resistance, corrosion resistance, robustness, and good toughness and fatigue resistance. It is strong but flexible, weight and texture is very close to human bone, even if subjected to collision will not appear dented or deformed, PEEK cranial repair perfect to make up for the shortcomings of titanium mesh. PEEK material is far superior to titanium mesh because of the repair aspect, so PEEK is still a more appropriate choice, it is recommended that patients and friends early treatment.