Smallpox and chickenpox are not the same disease as they have different causes, symptoms and treatments. 1. Causes: Smallpox is mainly associated with smallpox virus infection. Chickenpox is mainly related to varicella-zoster virus infection. 2. Symptoms: Smallpox patients will first have headache, fever, fatigue and other symptoms, followed by maculopapular rash, which will gradually change into blisters and pustules. Children with chickenpox will have fever, red papules, macules and pustules. Adults with chickenpox will first have symptoms such as loss of appetite and chills, and then enter the rash stage, which is relatively milder than smallpox. 3. Treatment: Smallpox patients can take antiviral drugs such as Tecovirin, for patients with bacterial infections can be used topical mupirocin, erythromycin and other antibiotic drugs. Chickenpox has a certain degree of self-healing, you can take acyclovir and other antiviral drugs treatment. Smallpox has been eliminated. If you want to know more about smallpox and chickenpox, it is recommended that you consult a doctor at a regular hospital to clarify the relevant matters.