Swelling and pain in the joints of both toes is considered to be caused by acute gouty arthritis, rheumatoid arthritis and other diseases. 1. Acute gouty arthritis: in addition to the phenomenon of swelling and pain in the toe joints, the patient will also be accompanied by an increase in skin temperature and local redness and swelling and other obvious manifestations, mainly due to high blood uric acid levels. Can go to the hospital to do blood uric acid level check, if there is high uric acid can take diclofenac sodium extended-release tablets for treatment, at the same time, external use of diclofenac sodium ointment to reduce the symptoms. 2. Rheumatoid arthropathy: In the presence of toe joint swelling, most patients will also be accompanied by joint deformation and stiffness and other symptoms, need to do immunoglobulin and blood sedimentation and other related tests, diagnosed after taking Liuzisulfonylpyridine enteric-coated tablets, for treatment. When there is unexplained swelling and pain in the joints of both toes, it is necessary to be admitted to the hospital immediately to receive a detailed examination, and according to the results of the examination, to formulate appropriate treatment measures under the guidance of the doctor.