The cranium is a hard helmet for the outer layer of the brain, always protecting our brain from the outside world. However, dangers are everywhere and there are always subjective or objective factors that may lead to cranial defects in the skull. If the skull is not repaired for a long time, it may cause many discomforts, which will bring a lot of trouble to our health and life. There are more discomforts arising from cranial bone loss. The visible disadvantage is undoubtedly the unattractive appearance, and the patient will become more inferior and depressed in the long run. Moreover, without the protection of the skull, the brain may be in danger at any time, especially if it suffers from the impact of sharp objects, it will injure the brain tissue and even threaten the safety of life. In addition, the integrity of the cranial cavity is seriously damaged after the skull is missing, and the intracranial environment as well as intracranial pressure become very unstable, which will directly affect the circulation of cerebrospinal fluid and blood in the patient’s skull, and the normal operation of the brain and nerve function may be affected, thus causing a series of craniosynostosis syndromes. For example, the patient will feel dizziness and headache, numbness and weakness of limbs, easily irritable, and also have vision, hearing and smell disorders, and in serious cases, epilepsy may be induced. The harm caused by missing skull is difficult to assess, timely to the hospital to do cranial bone repair surgery is particularly important, from the point of view of the current level of medical care, local hospitals can also carry out this surgery, but there are many shortcomings, due to the selection of improper materials or lack of experience, resulting in the effect is not very satisfactory. And the emergence of polyether ether ketone peek material, very good to make up for the previous defects of various materials, become the ideal material for cranial bone repair. The material has the advantages of three-dimensional printing, similar to the autologous skull, high temperature resistance, etc., so that the patient to restore the integrity of the skull, to achieve good therapeutic results.