The skull is an important protective barrier for the brain, and cranial defects are bound to have a great impact. Once a cranial defect occurs, patients should have cranial repair surgery in time. When doing skull repair surgery, the choice of material will constrain to the effect after surgery, patients should be careful with this issue. From ancient times to the present, cranial bone repair surgery has become more and more mature, and the materials used are also developing in the direction of safer and more advanced. Currently, many hospitals use titanium mesh for skull repair surgery. Although titanium mesh is more advanced than the earlier materials such as bone cement, artificial bone and plexiglass, there are many unavoidable problems. Exposure of titanium mesh is one of the most common, and many people have experienced exposure after using titanium mesh for cranial bone repair surgery in the clinic. Exposed titanium mesh is a more serious problem. If it is not taken out in time, the exposed part is prone to infection, leading to local inflammation, and it is also easy to expose the brain tissue to external aggression, which is a very dangerous situation. Therefore, in the case of exposed titanium mesh, patients must go to the neurosurgery department for another examination in time, so that the experts can remove the exposed part in time and carry out the repair work. There are many limitations to the use of titanium mesh materials, and a safer material is needed instead. At this time, the polyether ether ketone material (peek material) appeared, after a lot of clinical practice, peek material is currently the ideal material for cranial bone repair, it is quite excellent in all aspects of the performance of the postoperative patients will not have any discomfort, has a high evaluation. The emergence of peek material, successfully avoided the various defects of titanium mesh material, is a major breakthrough in medicine. peek material’s physical and chemical properties are comparable to the autologous cranium, and it also has the function of three-dimensional reconstruction, according to the situation of different patients personalized shaping, postoperative effect is more ideal.