Lung cancer clinical trial enrollment is generally a good thing, but there are some unavoidable problems. Benefits of clinical trial enrollment for lung cancer patients: first, before the promotion of new anti-cancer drugs, lung cancer patients will get new treatments and more chances. Secondly, in the course of clinical trials, doctors will frequently conduct various examinations for patients to monitor the development of the disease, which are free of charge and can save some medical expenses for patients. Of course, there are some unavoidable problems associated with clinical trial enrollment. First, because of the standardization and strictness of enrollment, the review of the project team will take some time, which may be delayed for patients with rapid disease progression. Secondly, the new drugs may have some serious side effects and may not be able to achieve the expected results. Finally, the drugs used in the control group are either standard treatment regimens or placebos, and the benefit to patients may be suboptimal. In conclusion, clinical trial enrollment can still be beneficial for some lung cancer patients with difficult family conditions and unsatisfactory treatment. Consultation with a medical professional is needed for specifics.