Patients with bile duct stones may experience bitter mouth symptoms, depending on the specific cause of the patient’s illness. If bile excretion is abnormal due to bile duct stones, bile may reflux into the stomach and cholestatic reflux gastritis occurs, at which time symptoms of bitter mouth may occur when bile damages the gastric mucosa. Choledocholithiasis is a common biliary tract disease in China, caused by bile stagnation and biliary tract infections that lead to the formation of stones in the intrahepatic and extrahepatic bile ducts. The most common symptom is pain in the upper abdomen or hidden pain in the upper abdomen. When patients have these symptoms, they should go to the hospital in time. If diagnosed, the cause of the disease should be clarified and treatment should be carried out under the guidance of the doctor. Focus on symptomatic changes in daily life and review regularly.