High indirect bilirubin may be caused by hepatitis B, but it cannot be diagnosed by just one indicator. Indirect bilirubin is one of the important items in liver function tests, but there are many factors that can cause high indirect bilirubin, and the presence of high indirect bilirubin can not be sure that hepatitis B patients. Higher indirect bilirubin is often seen during the exacerbation of hepatitis B. At this time, timely treatment should be taken to avoid the deterioration of the condition. In addition, high indirect bilirubin may also be related to poor diet, hepatitis, cirrhosis, hemolytic anemia, neonatal jaundice and so on. Therefore, patients with high indirect bilirubin should further clarify the cause and be given targeted treatment by doctors.