Always feeling that you have AIDS is also known as AIDS phobia in clinical practice. The patients mainly suspect that they have AIDS, and will keep going for examination again and again, including the antibody test for AIDS, and the test does not find any signs of AIDS infection, but the patients still feel painful. Clinically, these people often have irrational cognition, that is to say, they have catastrophic and absolute cognition about AIDS. The patients’ ability to socialize is significantly reduced, and they sometimes refuse to participate in various activities because they are afraid of contracting AIDS. Psychotherapy and medication are used to treat this condition. Psychotherapy mainly adopts cognitive behavioral therapy to improve patients’ irrational cognitive patterns and rebuild the cognitive system to achieve therapeutic effects. Drug treatment is mainly based on anti-anxiety drugs, mainly the application of lorazepam, alprazolam and other drugs, or antidepressant drugs such as paroxetine, sertraline and so on, with good therapeutic effect.