Prolonged inhalation of budesonide may lead to oral candida infections, hoarseness, increase the incidence of related diseases such as pneumonia, or lead to other side effects, but the incidence is not high enough to be prevented on a regular basis. 1. Oral Candida infection: Budesonide is a glucocorticoid drug, residual in the mouth can cause oral candida infection. 2. Hoarseness: long-term inhalation of budesonide, the drug is deposited on the vocal cords, may also cause hoarseness and other related adverse reactions. 3. Increased incidence of pneumonia: long-term inhalation of budesonide may also lead to increased incidence of pneumonia and other related comorbidities. 4. Other side effects: it cannot be ruled out that it may affect blood sugar to some extent. Therefore, in the process of long-term inhalation of budesonide also need to pay attention to the prevention of side effects of the drug, such as timely gargling after inhalation of the drug in order to remove the liquid produced in the oropharynx, which can reduce the incidence of the above adverse reactions.