Sildenafil and Dapoxetine can be used at the same time, but the specific frequency, dosage and time of use should follow the doctor’s instructions. Because sildenafil and dapoxetine use at the same time will make the adverse effects of the drug will be superimposed, will cause more serious hypotension, headache, dizziness, nausea, diarrhea and other adverse effects will also be aggravated. Sildenafil belongs to the type 5 phosphodiesterase inhibitor, through the inhibition of cavernous PED-5, so that the cavernous smooth muscle relaxation, blood inflow and make the penis erect, used to treat erectile dysfunction. It is prohibited to take sildenafil concomitantly with nitrate (regardless of whether the latter is used regularly or intermittently). It is prohibited for those who are allergic to the product. Dapoxetine is a selective 5-hydroxytryptamine inhibitor, which plays a role in the treatment of premature ejaculation and poor ejaculatory control in men by reducing the sensitivity of the sperm-control center, glans and seminal vesicles. This product is contraindicated in patients with heart failure, significant myocardial ischemia and moderate to severe hepatic impairment. In conclusion, patients should use the drug under the guidance of a professional physician and strictly follow the medical advice.