Increased urine output after applying hormone therapy for nephrotic syndrome may be an improvement of the condition, which is normal at this time; or it may be a side effect of the drug, which is abnormal at this time.
Nephrotic syndrome may be caused by primary glomerulonephritis or secondary nephropathy, and most of them are induced by autoimmune reasons, so glucocorticoids can be applied for immunosuppressive treatment.
The increase in urine output may be due to the reduction of urinary protein after the hormone effect, and the recovery of hypoproteinemia, which leads to an increase in urine output, which is a normal situation.
It may also be a side effect caused by a large number of hormone application, glucocorticoids have a weak saline corticosteroid effect, at the same time, glucocorticoids can reduce the resistance to blood flow in small glomerular arteries, increase renal plasma flow and glomerular filtration rate, and inhibit the secretion of vasopressin, which can lead to an increase in the amount of urine.
Increased urine output with hormone therapy requires electrolyte monitoring to prevent electrolyte disorders due to increased urine output. Patients with nephrotic syndrome are advised to standardize their treatment under the guidance of a physician.