The culprit of hyperandrogenism Excessive androgen levels and enhanced activity in women’s blood are called hyperandrogenemia. 1. Ovarian factors: polycystic ovary syndrome (PCOS) is the most important cause of hyperandrogenemia in women, and 70%-80% of PCOS patients are accompanied by hyperandrogenemia. Secondly, there are androgen-secreting ovarian tumors, which are generally small in size and not easily detected, so a significant increase in androgen determination can help in the diagnosis. Adrenal factors: congenital adrenocortical hyperplasia (CAH) and cortisolism are not only symptoms of hyperandrogenism, but also symptoms such as “full moon face and buffalo back” in some patients. The primary manifestations of hyperandrogenism are hairiness, acne, and androgenetic alopecia, which are the typical skin manifestations of hyperandrogenemia, especially the hairiness on the limbs, pubic area and armpits, and the embarrassing hairiness on the upper lip, nipples and abdomen. Acne is more common in adolescent patients, so mothers, when your child has long-term persistent acne, accompanied by irregular menstruation, it is likely to be a high androgen skin manifestation, and you need to go to the hospital for the appropriate examination! 2. Irregular menstruation and infertility. High androgens interfere with the growth and development of female follicles, leading to ovulation disorders and luteal insufficiency. 3, masculine characteristics androgens will lead to the appearance of some male characteristics in women, such as low voice tone, prominent laryngeal nodes, pubic emperor hypertrophy, male type pubic hair distribution, temporal baldness, and even cause the patient’s breast atrophy. 4. Bad pregnancy outcome Women should know that even after normal pregnancy, high androgens will affect pregnancy, which is likely to lead to miscarriage, and may also lead to fetal problems in gender differentiation and fetal malformation. Long-term hazards: 1. Long-term hyperandrogenism may cause metabolic disorders in patients, predisposing them to obesity, hypertension, dyslipidemia and coronary heart disease, increasing the morbidity and mortality of cardiovascular diseases. 2, endometritis high androgens interfere with female ovulation, long-term non-ovulation leads to continuous endometrial hyperplasia, which may even develop into endometrial cancer at a later stage. 3.Psychological problems infertility, abnormal menstruation, masculine features, miscarriage, and long-term disturbance of cardiovascular disease will certainly increase the psychological burden of this category of patients, with higher depression and suicidal tendency than normal people. Therefore, it is necessary to take a detailed medical history of these patients, so as to detect the “tip of the iceberg” and treat them accordingly.