Lymphoma is technically called “lymphoma”, which is a malignant tumor. There are two major types of lymphoma: Hodgkin and non-Hodgkin lymphoma. Lymphoma is a common cancer. In 2010, statistics in the United States reported that there were 74,000 lymphoma patients in the United States in a year, of which 65,500 were due to non-Hodgkin’s lymphoma; 21,500 people died of lymphoma in a year, of which 20,200 died of non-Hodgkin’s lymphoma. In China, too, the majority of lymphoma patients are non-Hodgkin’s lymphoma. From clinical practice, the number of lymphoma patients in China has been increasing year by year in recent years, and the 2nd Global Breast Cancer and Lymphoma Symposium in 2009 revealed that the incidence of lymphoma patients in China has increased from 11th to 9th among the top 10 most common tumors in men, and from 13th to 10th in women. Therefore, early diagnosis and treatment of lymphoma is very important. ”It is the psychology of most people to talk about cancer, and when people talk about lymphoma, they feel that the shadow of death is coming. As we all know, Luo Jing, the famous CCTV announcer, was diagnosed with lymphoma and died of the disease in just over 8 months. In fact, highly malignant lymphoma accounts for only about two-thirds of all lymphoma patients. At present, medical science has developed greatly, and many lymphoma patients are able to obtain long-term survival or even cure after regular treatment. For example, diffuse large B-cell lymphoma is a relatively malignant and common type of non-Hodgkin’s lymphoma, accounting for 1/3 of lymphomas; with the combination of anti-CD20 monoclonal antibody and chemotherapy, more than half of the patients have the possibility of cure. However, there are some patients who are refractory. The early symptoms of lymphoma are mainly swollen lymph nodes, which are not painful and often swollen in the neck, armpits and groin. About 60% of patients with lymphoma first notice swollen lymph nodes in the neck, starting with a single or a few, and gradually increasing in number. Fever of unknown origin is also an early symptom. Some patients with highly malignant lymphoma may rapidly develop high fever and jaundice, which are signs of an aggressive disease. Another early symptom that deserves attention is the presence of night sweats, which in layman’s terms means waking up from sleep and noticing sweating that is not caused by hot weather. Symptoms such as low-grade fever and night sweats are easily overlooked. Lymphoma can also invade other parts of the body. If it occurs in the stomach, small intestine or large intestine there may be gastrointestinal symptoms such as bloating, blood in stool, vomiting and abdominal pain; if it invades the bone marrow, it may produce symptoms of anemia such as pallor; if it occurs in the chest, there will be cough and shortness of breath, like the condition of Xiao Jiang. Another important misconception needs the attention of both patients and doctors. We found that many patients with lymphoma do not visit hematology or oncology hospitals at the onset of the disease. Some patients often visit quintuplegia, ophthalmology, surgery, etc. because of lumps found in the neck, eyes, abdomen, etc. Some of these patients are discharged after surgery to remove the mass in these departments. The key is that these patients are no longer discharged from the hematology or oncology hospitals to continue to see them for post-surgical treatment. Keep in mind that for most lymphomas surgery is not curative! Chemotherapy and immunotherapy must be used to cure lymphoma. There are some patients who delay the follow-up treatment because of the fear of chemotherapy, thus losing the chance of cure. In fact, a large proportion of lymphoma patients can be cured by chemotherapy and immunotherapy. We have analyzed in detail the situation of lymphoma patients attending the First Hospital of Zhejiang University School of Medicine and noted that many patients had only one chemotherapy or none at all after surgery. The survival time of these patients is very short and the best chance of treatment is lost for nothing. Special reminder to patients: you must go to a specialist (hematology or oncology hospital) for chemotherapy once you have lymphoma, and have about 6-8 courses of chemotherapy or chemotherapy combined with immunotherapy to have a hope of cure. Generally, patients with lymphoma should be reviewed every 3-6 months after achieving complete remission with chemotherapy or chemo-combined immunotherapy to prevent disease recurrence. In addition, there are many patients who choose Chinese herbal medicine for treatment because of the fear of chemotherapy. Chinese medicine has certain anti-tumor effects and is good for improving the patient’s immune function and resistance. However, it cannot cure lymphoma at root. Therefore, Chinese herbal medicine treatment can only be used as an adjuvant treatment, but not as the main treatment. Medical science is developing rapidly, and in recent years, scientists have conducted gene chip analysis research on lymphoma and discovered some new targets for the treatment of lymphoma. That means there are new ways to treat lymphoma. We applied proteasome inhibitor combined with chemotherapy to treat refractory lymphoma and achieved good efficacy, which obviously improved the cure rate of lymphoma. Looking ahead, with the development of science, the light of attacking lymphoma has been shown.