Systemic eczema itching is mainly treated with topical glucocorticoid preparations, which can be combined with antihistamines and immunosuppressants. Eczema is a chronic inflammatory disease, mainly involving the superficial dermis and epidermis, eczema can cause intense itching, the treatment is mainly external glucocorticoid preparations. Depending on the severity of the disease, different strengths of glucocorticoids need to be used. For example, mild eczema can use weak glucocorticosteroids, such as dexamethasone, hydrocortisone and so on. Moderate eczema can be treated with medium-acting glucocorticosteroids such as triamcinolone acetonide. Strong glucocorticosteroids, such as halometasone, may be used for severe eczema. Oral antihistamines such as loratadine and cetirizine can be used when itching is significant. If necessary, it can be combined with drugs such as Paeonia lactiflora, Radix Rehmanniae, Glycyrrhiza glabra and so on. When the above treatments are ineffective, serious and generalized rashes, systematic use of glucocorticosteroids and immunosuppressants can be considered. Specific therapeutic drugs need to be based on the condition, it is recommended to consult a doctor in a timely manner, and follow the doctor’s instructions for medication.