The causes of second toe pain may be related to physiological factors, or may be caused by diabetic peripheral neuropathy, atopic synovitis and other reasons. 1. Physiological factors: for example, wearing shoes that do not fit properly, resulting in the second toe being squeezed for a long time, may cause the second toe pain. The second toe pain may also be caused by excessive fatigue of the soft tissues and tendons of the foot due to factors such as walking or running for a long time over a long distance. 2. Diabetic peripheral neuropathy: diabetes can lead to peripheral nerve damage, resulting in peripheral nerves can not get enough blood and oxygen supply, resulting in sensory impairment of the nerve endings, which may be manifested in the second toe pain. 3. Atopic synovitis: usually caused by gouty diseases or rheumatic diseases, which can lead to lesions in the joints of the toes and may cause second toe pain. The second toe pain may also be caused by other reasons, including the second toe fracture and toe soft tissue trauma, etc. If accompanied by obvious discomfort symptoms, you should consult a doctor as soon as possible to confirm the cause of the disease, and then the doctor refers to the treatment.