The common causes of ankle swelling after running include over-exercise, soft tissue injury, bone fracture, varicose veins of the lower limbs, etc. According to the different causes of the disease, the treatments are also different, including proper rest, medication, surgery and so on. 1. Excessive exercise: after running for a long time, there is transient synovial edema in the ankle joint and lactic acid accumulation in the muscle, which can cause mild swelling and pain in the ankle joint, which is a normal phenomenon, and it is possible to take proper rest and warm up sufficiently before exercise. 2. Soft tissue injury: If the ankle joint is accidentally sprained during running, it will cause soft tissue injury around the ankle joint and capillary rupture, which will cause swelling and pain in the ankle joint. You can reduce activities, apply cold compresses intermittently within 72 hours and hot compresses on the ankle joint after 72 hours, which is conducive to swelling, and you can apply ointment that activates blood circulation and removes blood stasis to reduce swelling and relieve pain, such as chasing the wind ointment. 3. Fracture: If you have a history of osteoporosis and fall or sprain accidentally during running, there is a possibility of fracture of tibiofibula and talus, which may cause ankle swelling, pain, difficulty in movement, etc. It is necessary to improve the X-ray examination to make sure the fracture needs to be reset, fixed in plaster or treated by surgery. There are many reasons for ankle swelling after running, it may also be related to varicose veins of the lower limbs, heart disease, kidney disease, etc. If the symptoms continue to be unrelieved, it is recommended to consult a doctor in time to clarify the cause of the disease and carry out targeted treatment.