I. Treatment 1. Hormone is usually listed as the drug of choice, but the effect is only transient, rarely completely relieved, and less than half of the cases of blood picture improvement. Recently, hormone shock therapy has been reported to be effective. Splenectomy is recommended for patients with severe anemia (hemolytic) or thrombocytopenia and recurrent infections, whose hematological improvement can be obtained in 80% of patients after surgery, and recurrent infections and calf ulcers are also improved. However, only 30-40% of patients can remain in remission during long-term follow-up, and the rest of the cases deteriorate again within a few years or die of infection. In recent years, it has been found that the deterioration after splenectomy is related to the presence of parasplenium, suggesting a hyperactive state of the reticuloendothelial system. 3, other therapies including anti-rheumatic agents, penicillamine, gold agents can be tried. However, immunosuppressants should not be used because the granulocytes are too low. Lately, it is reported that the combination of hormone and tretinoin can bring about better remission. 4, symptomatic treatment with the smallest possible antigenic antibiotics to control the infection, because many antibiotics can aggravate the immune response that already exists in the body, so the application of antibiotics to treat this disease infection must be carefully selected. The prognosis Felty syndrome arthropathy is often more serious than the general rheumatoid arthritis, more bone erosion and deformity, about 60% of patients in this disease have more than one secondary infection. The skin and the inhalation tract are the most common sites of infection, and there are liver function abnormalities. Most patients have mild to moderate anemia. The prognosis is poor.