Erythromycin ophthalmic ointment can be applied directly to the eye because it is an antibiotic ophthalmic ointment that can be used if there is a localized inflammatory reaction. It can be used if there is localized inflammation and is applied to the eye, either on the white of the eye or on the conjunctival sac. The eye ointment is used more often at night, once at night before going to bed, to provide some coverage of the antibiotic at night. During the day, antibiotic eye drops, such as levofloxacin or tobramycin drops, can be used, which is easier for people who work during the day. Because eye ointment can leave the eye with a sticky feeling after use, and vision may be blurred, it is still better to use eye drops during the day and eye ointment once at night before bedtime, which is a relatively better combination.