Treatment of herpes simplex virus is generally divided into the following two areas: 1. Systemic medication: you can take oral acyclovir, or oral valacyclovir, or famciclovir 250 p.p., and the course of treatment is usually 7-10 days. For more serious infections, intravenous drip acyclovir can be used, the course of treatment is generally 5-7 days; 2, topical drug treatment: topical drug treatment is often based on drying, astringent, to prevent secondary infection, when the blisters have not broken can be directly applied acyclovir cream, or spray ciclovir cream or furnace glycolate lotion, etc.. If the blister breaks down, exudes and crusts, you can apply boric acid solution as a wet compress first. If the blister is secondary to infection, apply an ointment such as Bactrim first.