Herpes simplex virus infection reduces recurrence but does not cure it completely. Herpes simplex virus infection is prone to recurrence when the body’s resistance decreases, and treatment is aimed at shortening the course of the disease, preventing secondary bacterial infection or systemic spread, and reducing the chance of recurrence and transmission. Oral antiviral drugs, such as famciclovir or famciclovir, and immunomodulators, including transfer factor, thymidine and interferon, are usually given to prevent or reduce recurrence. For frequent relapses, that is, more than 6 relapses in 1 year, antiviral drugs can be given as suppressive therapy, such as valacyclovir 500 mg/day orally, usually for 6-12 months continuously.