Itchy vulvar leukoplakia in 80s old women can be seen in vulvar leukoplakia, and vulvar moisture, low immunity, etc., also can be seen in vitiligo, diabetes, etc., need to consult a doctor in time to diagnose and treat, the treatment includes medication, life interventions. Elderly women with low immunity and moist vulva can cause itchy vulvar leukoplakia, and medication is mainly to control itching, such as topical medication such as florazepam ointment, clobetasol ointment and other glucocorticoid hormones, and immunosuppressant such as tacrolimus ointment can also be used. If the itchy vulvar white patches are caused by vitiligo, the treatment includes oral white spirit tablets, vitiligo pills, and also local use of glucocorticosteroids such as dexamethasone to stop the spread of white patches, or tacrolimus ointment, pimecrolimus cream and so on. If diabetes causes white patches of pubic skin with intense itching, mainly caused by poor control of diabetes, the treatment should actively control blood sugar, such as the use of insulin, acarbose, but also can be applied locally pimecrolimus cream. In daily life, we should change underwear regularly, keep the vulva clean and dry, standardize the use of medication under the guidance of the doctor, prohibit spicy and stimulating food during the onset of the disease, and use emollients to moisturize the skin at the same time.