The swabs used for nucleic acid testing, i.e., sampling swabs, do not have drugs on them. The CDC recommends that the swab head material should be made of synthetic fibers, that the swab handle should be synthetic or metal, and that the use of calcium alginate swabs or swabs with wooden shafts may contain substances that inactivate certain viruses and reduce accuracy. Sampling swabs in common use today look similar to ordinary cotton swabs, but the tip is actually a flocked swab. Flocked swabs use short nylon fibers that are held vertically at the front of the swab so that there are no absorbent holes in the entire collection area of the swab, and the collected sample will not be dispersed and retained in the fibers, which facilitates faster and more efficient elution, making it more suitable for sampling and testing. Sampling swabs belong to medical devices, the basic requirement of qualified products is non-toxic and harmless. Moreover, the sampling swab itself does not contain any soaking reagent, nor does it need to contain reagents.