Every Tuesday, a 70-year-old man, Lu Bo, comes to the hematology clinic of Wuyi Hospital for a follow-up consultation. After a series of examination, he was diagnosed as acute severe immune thrombocytopenic purpura (ITP), which was given blood transfusion and glucocorticoid treatment without significant improvement. After the patient’s admission, the standard dose of glucocorticosteroid treatment was not satisfactory, and a series of related adverse effects appeared: diabetes mellitus and hypertension; the dosage of hormone was gradually reduced; after one course of chemotherapy with VP regimen, there was still no significant improvement; considering the complexity of the patient’s condition, the doctors of the department discussed and formulated a systematic and strict treatment plan, decisively discontinued the hormone, and added a combination of Chinese herbs with the effects of draining wind and clearing heat, cooling blood and stopping bleeding through evidence-based treatment. However, due to the high cost of the injection of recombinant thrombopoietin, it was discontinued at the end of the 3-month free use period, and the patient continued to use Chinese herbal medicine for evidence-based treatment. However, after two weeks of herbal discriminative treatment, the patient’s platelet count gradually recovered again, and the platelets are still stable between 70-100×109/L, and daily life is not affected. Immune thrombocytopenia is a kind of refractory blood disease, the conventional treatment is to use glucocorticoids or immunosuppressants to suppress the abnormal immune response of the body, but the efficacy is often limited or hormone dependence and resistance phenomenon occurs, while Chinese medicine has its unique efficacy in the treatment of this disease, the clinical use of Chinese medicine intervention, the combination of Chinese and Western medicine treatment can play a significant role in reducing toxicity and increasing effectiveness, can It can effectively reduce the transformation of acute patients into chronic refractory patients, and reduce hormone dependence and hormone resistance in chronic refractory patients.