Chronic nephritis caused by high uric acid, the main treatment is to reduce uric acid and treat various nephritis complications, such as renal hypertension, renal anemia, etc. If the condition progresses to uremia, renal replacement therapy is needed. Hyperuricemia can lead to chronic nephritis, mainly manifested as renal interstitial damage, the treatment first need to reduce uric acid, can apply allopurinol, febuxostat and other drugs. If it has caused chronic renal insufficiency leading to various complications, it also needs to be actively treated to try to delay the decline of renal function. For example, patients with renal hypertension can be treated with calcium channel antagonists (nifedipine extended-release tablets) or renin-angiotensin-aldosterone system inhibitors (valsartan, benadryl), and patients with renal anemia can be treated with erythropoietin or roxarestat. If the patient’s renal function decreases more and has reached the degree of uremia, renal replacement therapy such as hemodialysis and peritoneal dialysis is needed. It is recommended that patients should consult the hospital in time and follow the doctor’s instructions for standardized treatment, and the above medication should be used according to the doctor’s instructions, not without authorization, so as not to aggravate the condition.