The pain between the anus and the testicles, also known as perineal pain, is usually caused by these reasons. First, urinary tract infection, urethritis can lead to perineal pain; second, urethral stones can also cause anal or perineal pain; third, chronic prostatitis. Chronic prostatitis can appear urinary abnormalities, such as urinary frequency, urgency, urinary pain, urinary divergence, increased frequency of nocturia, can also lead to lumbosacral and perineal pain; fourth, skin surface infections, such as anus and testicles between the perineum of the skin occurs in localized infections, which can lead to redness and swelling, there will also be pain. Therefore, when pain occurs, go to the hospital to do a detailed physical examination to see what specific causes, and give symptomatic treatment.