Patients with pancreatic cancer combined with liver metastasis can be treated with radiotherapy, which can improve the symptoms of some patients, and its role in delaying recurrence and improving prognosis is still controversial. Pancreatic cancer can metastasize to the liver through the blood system lymphatic system, and those with combined liver metastasis are in advanced stage. Neoadjuvant treatment of pancreatic cancer before surgery usually does not choose radiotherapy, and some studies say that chemotherapy can be combined with radiotherapy as a neoadjuvant treatment. Postoperative local radiotherapy for pancreatic cancer does not completely kill tumor cells, and its role in delaying recurrence and improving prognosis is controversial and lacks high-level evidence support. Postoperative adjuvant radiotherapy can be given to those with residual tumor, regional lymph node metastasis, vascular or nerve invasion according to the situation. For localized lesions invading nerves, local radiation therapy can relieve patients’ pain and other symptoms, thus improving patients’ quality of life. Although pancreatic cancer with liver metastasis is in advanced stage and cannot be cured, radiotherapy can still improve the quality of life of some patients. It is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions to control the disease progression and improve the patient’s prognosis.