Glomerular diseases are a group of diseases with different etiology, pathogenesis, clinical manifestations, pathological changes, course and prognosis, mainly involving the glomeruli of both kidneys, and can be classified as primary, secondary and hereditary. Primary glomerular disease is often of unknown cause; secondary glomerular disease refers to glomerular damage caused by systemic diseases; hereditary glomerular disease is caused by heredity. Primary glomerular disease accounts for the majority of glomerular diseases and is still the most important cause of chronic renal failure in China. It has four main clinical manifestations, the first is proteinuria, the second is hematuria, the third is edema, the fourth has hypertension, and the fifth part can appear some kidney function impairment. In terms of treatment, the cause of primary glomerular disease is unclear, mostly some immune inflammatory diseases, its treatment principle is still mainly hormones and cytotoxic drugs, or hormones plus cytotoxic drugs as the main line, according to different pathological types, the treatment plan is also different. While treating, we should not only eliminate the clinical symptoms of patients, but also try to prevent and reduce some complications such as infection and thromboembolism, and try to protect the kidney function and delay the development of kidney function. The principle of secondary glomerular disease treatment is mainly for the treatment of the primary disease is the first important, for the kidney damage caused by the primary disease, we have to go to treatment according to the corresponding condition. We also need to pay attention to it primary disease, the kidney damage brought about during the treatment and examination of systemic diseases.