There are many reasons for coughing in the middle of the night, such as cough variant asthma, cardiac insufficiency, gastroesophageal reflux disease and so on. For different causes of cough, the treatment method is different. 1. Cough variant asthma: it is a special type of asthma, which is mainly characterized by irritating dry cough, mostly occurring at night and in the early hours of the morning, without obvious symptoms such as wheezing and shortness of breath. It can be treated with inhaled glucocorticoids (e.g. budesonide) combined with bronchodilators (e.g. salbutamol). 2. Cardiac insufficiency: the cough in the middle of the night is mainly caused by the change of body position, which leads to blood stagnation in the lungs, causing pulmonary stagnation and edema, thus causing cough in the middle of the night, which can be alleviated by adopting the sitting position. 3. Gastroesophageal Reflux Disease (GERD): when lying down, acidic reflux material may reflux into the throat, stimulating the throat and trachea, causing cough in the middle of the night, pharyngeal discomfort and other symptoms. Coughing can be reduced by inhibiting gastric acid secretion such as omeprazole and promoting gastric motility such as domperidone. There are many reasons why you keep coughing in the middle of the night, you should go to the hospital in time to clarify the cause of the disease, and under the guidance of the doctor to avoid delaying the condition. The drugs appearing above also need to be administered under the guidance of a doctor.