With age, human skin will appear wrinkles, especially facial wrinkles, such as crow’s feet under the eyes, decrees, head lines, etc. At this time, wrinkles can be eliminated and youthful skin can be restored through the method of wrinkle removal injections. There are many kinds of injectable components of wrinkle removal needle, such as collagen, botulinum toxin and hyaluronic acid, such as botulinum toxin can inhibit the release of acetylcholine from the presynaptic membrane of peripheral motor nerve endings, blocking the information transmission between nerves and muscles, thus causing paralytic relaxation of muscles, which can effectively eliminate the aging of human facial skin due to various reasons, such as wrinkles and depressions caused by skin; hyaluronic acid belongs to a gel-like substance that can store water for Hyaluronic acid is a gel-like substance that can store water for the skin, making it look hydrated and elastic. Generally, there will be no adverse consequences after the wrinkle removal injection, however, due to the richer nerves and blood vessels in the eyes, coupled with individual differences, some people will have adverse reactions, leading to certain hazards, such as local swelling of the eyes, as well as bruising and numbness at the injection point, such as infiltrating into non-target muscles to appear one high and one low eyebrow, temporary protrusion of lower eye bags, etc. In serious cases, double vision, swallowing and breathing difficulties will also occur. Therefore, it must be operated by an experienced physician to reduce adverse consequences.