The symptoms of blisters and pain in the anus are considered to be a sign of thrombosed external hemorrhoids. This kind of blister is blood red or dark purple with obvious swelling and pain around it, its due to prolonged dry stool, constipation, varicose veins around the anus and poor blood circulation forming thrombus. Its symptoms are mild and can be treated with oral pain medication first, while surgery is required in severe cases. Perianal abscess can also appear as a localized pus blister with obvious redness and pain around it, caused by bacterial infection due to untimely local cleaning. It needs to be treated with oral antibiotic medication and surgical incision and drainage if necessary. In addition, internal hemorrhoids can also manifest as anal blisters when there is an anal impaction, which is a manifestation of the nucleus pulposus. It needs to be treated promptly at the hospital and returned to the nail or surgically. The actual cause of the hemorrhoids, regardless of the specific one, needs to be seen in the hospital and treated symptomatically in time, and can be treated with local heat.