Nursing measures for patients with chronic renal failure are as follows: 1, rest more, avoid overwork; 2, give high quality low protein, high calorie, high vitamin, easy to digest, low purine, high calcium diet; 3, closely monitor the patient’s vital signs, accurately record the 24-hour fluid intake and output, measure body weight on a daily basis, and observe whether there is any disturbance of electrolyte-acid-base balance, as well as signs of infection; 4, strengthen the skin care, pay attention to personal hygiene, take a bath, change clothes and do manicure. Pay attention to personal hygiene, take bath, change clothes and trim nails frequently. Protect the edematous parts of the skin, if itching occurs, follow the doctor’s advice to apply antipruritic agent, do not scratch; 5, follow the doctor’s advice to use medication, observe the efficacy of the drugs and adverse reactions; 6, strengthen psychological care, correctly treat the disease, and maintain optimistic mood.