The skull is one of the hardest bones in our body and plays an important role in protecting brain tissue and maintaining a stable intracranial environment, which is vital for normal life functioning. Therefore, if a cranial defect occurs, it should be repaired in a timely manner. In addition, the soft tissues inside the skull are not protected by the hard shell and may be easily damaged by external forces; secondly, the unstable intracranial pressure caused by skull defect may also affect the normal operation of the life activities inside the skull. The external manifestation is that it may lead to frequent headache and dizziness, in addition to the patient’s fear of pulsation, expansion and collapse of the defect area, as well as fear of sunlight, vibration and even noisy sound. It may also cause lack of concentration and memory loss, and some patients show depression, fatigue, reticence and low self-esteem. This is why it is essential to perform skull repair surgery in a timely manner after a skull defect. We often perform cranial repair surgery, and PEEK is used clinically as the implant material for cranial repair. The detailed steps of the skull repair surgery: first anesthesia, sterilization, then incision of the scalp, exposure of the bone window, take the preoperative three-dimensional shaped polyetheretherketone PEEK repair piece, according to the shape of the patient’s skull defect adjustment reset and fixed, suture the scalp, surgery is completed. It is important to emphasize that not only is it important to standardize the detailed steps of cranial repair surgery, but also the materials used for cranial repair are important. Our widely used polyether ether ketone PEEK material is a very excellent material, which can be shaped in three dimensions according to the patient’s skull data and highly restore the anatomical structure of the skull, in addition, its performance in elasticity, hardness, heat insulation, stability and other aspects is basically the same as the autologous skull, there is no rejection reaction, and will not interfere with CT, nuclear magnetic examination, etc. It is an excellent cranial bone replacement material and has become the new favorite in the cranial bone It is a new favorite in the world of cranial bone repair.