Multiple myeloma is a more serious disease that is actually a neoplastic disease of the hematological system. A hematologic tumor is a non-solid tumor, not really a substantial tumor, but a neoplastic disease caused by an abnormality in the hematologic system. Multiple myeloma, first of all, is a plasma cell tumor, that is, this tumor cells are plasma cells, and this disease causes severe pain, often as a multiple fracture site. The characteristics are called CRAB, where C is hypercalcemia, R is renal impairment, A is anemia, and B is bone impairment. Therefore, multiple myeloma will eventually bring about bone damage. The characteristic imaging manifestations, such as chisel-like changes, are most often seen in the skull or flat bones with many small holes, chisel-like X-ray manifestations, and of course in the spine will cause some non-leaping, continuous segmental lesions. Of course, the blood immunofixation electrophoresis is done, and there is an elevation of M protein. Neoplastic lesions of hematologic origin can cause very severe bone pain. Multiple myeloma can be treated very well with chemotherapy in hematology.