Hepatitis B DNA 1.23E+3 is suggestive of positivity. Whether it is serious or not requires a comprehensive assessment of liver transaminase levels and liver ultrasound findings to determine whether an antiviral regimen needs to be initiated. 1. Liver aminotransferase level: under normal circumstances, the replication number of hepatitis B virus is less than 1000 copies per milliliter, but if the liver aminotransferase level is more than twice the normal high value, and the replication number of hepatitis B DNA is increased, it is necessary to start the medication program, and the liver aminotransferase level and the replication number of hepatitis B DNA should be rechecked regularly. 2. Liver ultrasound test result: when the result of liver ultrasound test suggests fibrosis or cirrhosis has occurred, it is necessary to start antiviral treatment program as early as possible, clinically, antiviral drugs can choose entecavir, adefovir and other drugs, and pay attention to determine whether there is the problem of drug resistance. It is recommended to consult the Department of Infection of regular hospitals to determine whether it is necessary to take oral antiviral drugs if you find that the number of hepatitis B virus replication has increased, do not be negligent, so as not to delay the condition.