Lymphogranuloma is a sexually transmitted disease. The causative agent of lymphogranuloma is Chlamydia trachomatis, and the main cause of the disease is caused by unclean sexual contact, with the main symptoms being genital first sores and localized lymphadenopathy. Treatment includes systemic and localized therapy, and regular review is required after treatment. Lymphogranuloma, also known as inguinal lymphogranuloma, is an infectious disease caused by unclean sexual intercourse. The main mode of transmission is sexual contact. Early symptoms of lymphogranuloma are pimples or blisters on the genitals. As the disease progresses, vesicles or ulcers will form, which will heal in about 10 days without leaving marks. In the middle stage, the inguinal lymph nodes will be enlarged, and after 1-2 weeks, each inflammatory lymph node will be successively suppurated, necrotic and perforated. In the late stage, genital elephantiasis and rectal stenosis develop. Lymphogranuloma requires prompt medical attention, and treatment generally includes systemic and localized therapy. Systemic treatment involves taking drugs such as minocycline and erythromycin under the supervision of a doctor. For localized treatment, wash the affected area with potassium permanganate and apply erythromycin ointment under doctor’s supervision. For pus, pus can be punctured and extracted. Avoid coitus during treatment to ensure the therapeutic effect. Lymphogranuloma patients need to be reviewed regularly after treatment, so that they can find the symptoms in time and treat them in time. After treatment, pay attention to personal hygiene, keep the affected area clean; appropriate physical exercise, enhance the body’s immunity.