The most typical symptom of acute appendicitis is metastatic right lower abdominal pain, and the main treatment is surgical removal of the appendix. Typical acute appendicitis patients’ initial symptoms are mostly vague pain or distension around the umbilicus or in the stomach area under the raphe, which is still tolerable. Generally, the pain gradually shifts to the right lower abdomen and becomes fixed after 6 hours of the onset of the disease, and can be accompanied by different degrees of fever and diarrhea and other discomforts. However, there are some atypical appendicitis patients directly manifested as persistent pain in the lower right abdomen. In case of symptoms similar to those mentioned above, it is recommended to consult a general surgeon, who will usually find fixed pressure pain in the lower right abdomen, even abdominal muscle tension and rebound pain during abdominal examination, which is often a sign of peritonitis. When appendicitis is considered, further blood tests, urine tests, abdominal ultrasound or abdominal CT examination are needed to clarify the diagnosis. If the relevant examination is consistent with the abdominal physical examination, it is recommended to follow the doctor’s prescription of cefixime, metronidazole and other anti-infective and comprehensive treatment, if necessary, as soon as possible to perform appendectomy to avoid appendiceal perforation.