There are many medications for toothache, but toothache can be caused by a variety of conditions and requires medical attention to treat accordingly. Medications are only useful as an adjunctive treatment for some conditions. Commonly used drugs include cephalosporin antibiotics, nitroimidazole antibiotics and non-steroidal anti-inflammatory drugs, such as cefaclor, ornidazole and ibuprofen extended-release capsules. 1. Cephalosporin antibiotics: mainly for the treatment of infections caused by gram bacteria, belonging to the broad-spectrum antibiotics, the oral cavity is a variety of bacteria coexisting in a complex environment, the early stage of the streptococcus, staphylococcus aureus and other infections, cephalosporin has a certain degree of efficacy. Such as cefaclor, cefprozil, cefixime, etc., alcohol is prohibited during the medication, common nausea, vomiting and other gastrointestinal side effects, relieve after stopping the drug. 2. Nitroimidazole antibiotics: some oral infections in the late stage, anaerobic bacteria proliferation, nitroimidazole antibiotics are mainly drugs for the treatment of anaerobic bacteria, such as metronidazole, ornidazole; it is often used in conjunction with cephalosporin. Alcohol is prohibited during the medication, and common gastrointestinal reactions such as nausea and vomiting, and neurological discomforts such as dizziness are relieved when the medication is discontinued. 3. Non-steroidal anti-inflammatory drugs: mainly anti-inflammatory and analgesic effects, such as ibuprofen extended-release capsules; peptic ulcer patients with caution. Most of the drugs taken for toothache are alleviating the effect, the root cause also needs to be treated according to the cause of the disease, it is recommended to go to the regular hospital stomatology department.