The 12-year-old daughter’s face is full of pimples, mostly referred to as acne, belongs to the follicle sebaceous glands chronic inflammatory disease, mainly related to androgen levels, Propionibacterium acnes reproduction, genetics, etc.; clinically can be used in the general care, topical application of medication, internal medication treatment. 1. General treatment: 12-year-old children have exuberant oil secretion in the skin and more oil in the facial skin. Warm water or neutral cleansing milk can be used to clean the face to minimize the adhesion of oil and the blockage of pores. Avoid spicy and stimulating foods in your daily diet to avoid aggravating your condition. 2. Topical medication: mild acne can be applied externally with retinoic acid drugs, such as retinoic acid cream, adapalene gel, etc. Secondly, benzoyl peroxide can also be applied externally. 3. Internal medication: For patients with severe acne, oral isotretinoin soft capsule can be taken to reduce sebum secretion and control abnormal keratinization, to prevent the formation of blackheads and pimples. Specific treatment drugs need to be under the guidance of a professional doctor, according to the patient’s specific symptoms and causes of the disease, after a reasonable choice of medication.