There is no best medicine to eradicate Helicobacter pylori. Currently, commonly used drugs in clinical practice include antibiotics, bismuth and proton pump inhibitors. 1. Antibiotics: Commonly used antibiotics include amoxicillin, clarithromycin, metronidazole, tetracycline, etc. Taking this kind of drugs can play a role in inhibiting the growth of bacteria, and two antibiotics are usually used. 2. Bismuth: Bismuth is a kind of gastric mucous membrane protector, drugs containing bismuth include bismuth potassium citrate, compound bismuth aluminate, etc. Clinically, a bismuth is usually chosen in the treatment of eradicating Helicobacter pylori. 3. Proton pump inhibitors: these drugs are through the inhibition of gastric acid secretion, change the living environment of Helicobacter pylori, to achieve the purpose of removing Helicobacter pylori, common drugs include omeprazole, lansoprazole, pantoprazole, etc., usually choose a proton pump inhibitor. Warm reminder: there is no best medicine to eradicate H. pylori, and the common clinical treatment program is a quadruple therapy consisting of two antibiotics, one bismuth agent and one proton pump inhibitor. Once patients are diagnosed with H. pylori infection, they should be treated under the guidance of a doctor.