Patients with intrahepatic cholestasis during pregnancy have significant toxic effects on the fetus due to the markedly elevated levels of bile acids in the body, which can lead to serious consequences such as fetal growth retardation, intrauterine distress, preterm delivery, intracerebral hemorrhage in the newborn, and fetal or neonatal death. In addition, obstetric monitoring should be strengthened, the fetus should be dynamically observed at least once a week, and labor should be induced after 37 weeks of gestation, in principle, no later than the expected date of delivery. If abnormalities of the fetal heartbeat or suspected intrauterine distress are detected during pregnancy or in labor, a cesarean section is required to end the labor urgently. As for those who are induced during pregnancy or postpartum return, hormones should be prohibited.