By hormones, this article refers to glucocorticoid drugs, i.e. drugs that mimic the function of a hormone secreted by the human adrenal cortex. The human body also secretes many other hormones, which, although not covered in this article, can be similarly confronted with all hormones used as prescribed. There was an incident in Australia that, although more than a decade old, is still being recounted by doctors there. Gloria, like many babies, got eczema at four months of age, but because the parents were afraid of the side effects of hormonal drugs, they did not receive regular treatment. As a result, the baby’s eczema got worse and her nutritional status deteriorated. Although she was admitted to the hospital at the end of her life, it was too late: a large skin wound secondary to a severe infection led to her tragic death from sepsis. It is saddening to learn that a curable disease was delayed and the child lost her life due to the parents’ misperception. Of course, this is only an extreme incident, but it reflects that parents have a lot of prejudice against hormone creams, even to the extent of “hormone phobia”, after the child has eczema, do not cooperate with the doctor’s prescription of medication, delayed treatment, the child suffers from unnecessary crimes, and may cause serious consequences. In the clinic, we often see these poor children, because their parents are worried about the side effects of hormone creams, use friends recommended by a variety of cosmetic products claiming miraculous efficacy, as a result, eczema is getting worse and worse, or use hormone creams, a little bit better and then immediately stop the drug, as a result, eczema is not always under control. Why hormone phobia? Hormone creams have anti-inflammatory and anti-allergy, reduce rashes, reduce edema, stop itching and so on, which is a dermatological treatment of various inflammatory skin diseases. However, more than 40 years ago, when all kinds of topical corticosteroids were just launched, people still could not figure out the difference in the strength of action of these creams, which were regarded as “miracle drugs” at that time, and the characteristics of each hormone, so they abused them without distinguishing between parts, conditions and indications, and there were even some people who used hormone creams as cosmetic cosmetics for a long period of time, which led to the emergence of a large number of systemic and local side effects, which was also heavily reported by the scientific journals and social media at that time. This is one of the origins of “hormone phobia” among some doctors and patients. Hormones are not that scary! With a deeper understanding of the strength of action, dosage forms and other characteristics of various hormones, hormone creams have now been greatly improved over the previous ones. There are many types of hormone creams, and they are generally categorized into four types from weak to strong: weak, medium, strong and super strong. Generally speaking, the stronger the effect, the more significant the anti-inflammatory effect, but the side effects are also relatively larger, which needs to be selected according to different diseases and the area to be smeared. For pediatric eczema, weak- and medium-acting hydrocortisone acetate, dieldrin and hydrocortisone butyrate can be used. Although mometasone furoate ointment belongs to the strong-acting category, it has been found to have fewer side effects compared to other strong-acting medications, and has been referred to as a ‘soft hormone’ by many dermatologists, which can also be used for children’s eczema. In terms of dosage forms, ointments are preferred, followed by creams. Gels and other dosage forms are poor moisturizers, and if they must be used, a layer of moisturizing cream needs to be applied after the gel. The side effects of topical hormones are both local and systemic. Theoretically, the area where the drug has been applied for a long time may experience thinning of the skin, lightening of the skin color, or even redness and inflammation. If skin atrophy occurs, stop the drug in time, after a few months will slowly recover. Systemic side effects are often said to become fat stomach, buttocks become bulging, osteoporosis, easy to infect, children do not grow high, but the vast majority of these side effects are not the correct use of hormones, or the use of unknown ingredients containing potent hormone cosmetics caused. Pediatric eczema is one of the most symptomatic diseases of topical hormones, personal experience and literature reports have proved that: reasonable use of medication will not appear skin atrophy, hypopigmentation and other side effects; rare cases of long-term and excessive use of potent and ultra-potent hormone creams will appear in the armpits and other skin folds in the skin wrinkles of the skin lines, transient belly fat and red spots around the mouth acne. How long is long term? This question needs to be combined with the age of the child, the area of application and the medication used. It is generally believed that weak and medium-acting hormones can be applied once or twice a day for three to four weeks; strong hormones can be used for two weeks in a row. Generally, after the disease is under control, the medication can be stopped according to the specific situation. Repeated episodes of children can be in the control of the disease, the intermittent use of hormone ointment to prevent recurrence, such as two days a week, stop five days, a study has proved that the use of such a five-year, the child is safe. For the current situation, topical glucocorticoid creams are recognized as the first-line drugs for the treatment of pediatric eczema, following the doctor’s advice to use the appropriate topical hormone medication, not only but also effective, but also safe. All-natural products are not safe! Businessmen are very smart, they take advantage of parents’ fear of hormones to produce and promote the so-called natural, pure Chinese medicine, hormone-free so-called eczema “miracle drug”, but these natural products are likely to secretly add hormones. The use of these products is not only spend more money, more importantly, unknowingly use the composition of unknown, unclear side effects of the “drug”, which is the biggest taboo on the rational use of drugs. In short, the current treatment of pediatric eczema, as opposed to the overuse of hormones, more often than not, the use of inadequate. Of course, the use of hormonal creams under the guidance of a doctor, together with active and rational moisturizing, can have a positive effect on maintaining the skin barrier, preventing and reducing the allergic process.