65 years old creatinine 122μmol / L is considered high, 65 years old people generally less muscle content, so relatively speaking, 122μmol / L has been considered high. China’s adult male creatinine normal value of 53 to 106 μmol / L, women’s normal value between 44 to 97 μmol / L, different hospitals reference range varies slightly. Creatinine is a metabolite in the body, because its discharge and glomeruli have an important relationship, so generally can also be used to reflect the condition of the kidneys. It is related to physiological factors and pathological factors. 1. Physiological factors: recent large amount of high protein diet, eating more lean meat, strenuous activities, etc., will cause high creatinine, after vegetarian diet or rest to restore the normal health level. 2. Pathological factors: patients with chronic causes such as chronic glomerulonephritis, diabetic nephropathy, hypertensive nephropathy, etc., need to be treated symptomatically under doctor’s guidance, and review regularly to slow down the rate of renal progression. When creatinine 122μmol/L is found, it is recommended to go to the nephrology department of regular hospitals for comprehensive judgment by doctors, to clarify the cause of the disease, and to follow the doctor’s instructions for standardized treatment.