Duodenal bulb ulcer with severe weight loss may be caused by duodenal bulb ulcer, may also be malignant tumors, hyperthyroidism and other diseases caused by the need for targeted treatment under the guidance of the doctor, including drug therapy, surgical treatment, and so on. Duodenal bulb ulcers will appear decreased appetite, nausea, vomiting and other symptoms lead to eating less, resulting in wasting, at this time should be for the treatment of the primary disease, such as following the doctor’s instructions to take omeprazole, cimetidine and other acid inhibitors, aluminum sulfate and other gastric mucosal protectants, for the duodenal bulb huge ulcers or complications of perforation, bleeding and other cases need to consider surgical treatment. In addition, severe wasting also need to be alert to whether there are other pathologies, such as malignant tumors, hyperthyroidism, etc.; malignant tumors need to be considered for surgical resection, combined with radiotherapy; hyperthyroidism need to take antithyroid drugs, such as methimazole, propylthiouracil, etc. or iodine radiation therapy. Ulcer-induced malnutrition and wasting can strengthen nutrition. Duodenal bulb ulcers with severe wasting need to go to the hospital, please ask the doctor to clarify the cause of the disease, and give appropriate treatment measures.